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The National Alliance of Advocates
for Buprenorphine Treatment

Buprenorphine (Suboxone®, Subutex®3, Zubsolv®4, Bunavail™5, Probuphine®6) is an opioid medication used to treat opioid addiction in the privacy of a physician's office.1 Buprenorphine can be dispensed for take-home use, by prescription.1 This, in addition to the pharmacological and safety profile of buprenorphine, makes it an attractive treatment for patients addicted to opioids.2


Provided here are PDF files of literature for you to download and view or
print for your convenience.

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Over 3,000,000 downloads of this material so far!

Find a Buprenorphine Physician

Have a certified prescribing physician contact you. The Patient/Physician Matching System.
Find other local resources (physicians,
counselors, pharmacies, studies,
meetings, etc.)

NAABT Buprenorphine Basics

Buprenorphine BrochureAn introduction to buprenorphine as a treatment for opioid addiction, this brochure explains the basic history, laws, and pharmacology along with how to find a prescribing physician. (updated for 2015)

NAABT "Recovery is About Change"

Revovery is Change NEW for 2015

If the process of addiction recovery could be summed up in one word, it would be change. Without change there is no recovery.

Recovery from addiction is not achieved through the passage of time, nor taking a treatment medication, nor attending meetings. These are simply tools to help make profound changes in behavior and thinking. Understanding this provides the map necessary to navigate a successful recovery.

This paper takes an overall look at what recovery from addiction actually means, and what
matters, the purpose of counseling, therapy, support, and treatment medications.

NAABT "About Precipitated Withdrawal"

About Precipitated WithdrawalsWhat is it? How to prevent it. A must read for every patient before beginning buprenorphine treatment.

Page 2 is the COWS (Clinical Opiate Withdrawal Scale) to help in gauging withdrawal symptoms.

Hi-Resolution Color: 2MB
Black & White version (for patient's file) PDF: 64 KB

NAABT "The Words We Use Matter"

NAABT - The Words We Use MatterBy choosing language that is not stigmatizing, we can begin to dismantle the negative stereotype associated with opioid addiction. Explanations of why certain words and phrases are stigmatizing and suggestions for alternate, non-stigmatizing replacements are suggested as a start in reducing the stigma associated with addiction.

NAABT "How Buprenorphine Works"

How Buprenorphine WorksThe effect of buprenorphine on the brain is explained in an illustrative, concise fashion. (Updated 6/2007)

(Hi-Res JPEG image suitable for photo printers, 2MB)

PowerPoint slides of this can be downloaded as well.

The "Bowling Ball" analogy, written by Dr. Richard Gracer. Peer Support Brochure

Addiction Survivors"The Meaning of Peer Support. What is it? Expectations" discusses different types of peer support, and how it differs from therapy and the other components of a complete recovery plan.

NAABT Emergency Contact Wallet Card

NAABT - Emergency Contact Wallet CardThis important addition to a patient's wallet includes spaces for not only important contact numbers for the patient, but also important resources for healthcare workers unfamiliar with buprenorphine.

Directs healthcare workers in an emergency to:

NAABT Matching System Patient Registration Instructions (Counter Display Refills)

Counter Display Card4"x9" in size, side one is a brief description of buprenorphine, side two is an explanation of the NAABT patient/physician matching system.

Pharmacies can order these refills for their counter displays here

NAABT Matching System Physician Instructions

NAABT - PPMS Physician InstructionsThe NAABT Patient/Physician Matching System (PPMS) confidentially connects patients with participating certified buprenorphine-prescribing physicians. This instruction sheet shows how to register and use the system to contact patients seeking buprenorphine treatment.

SAMHSA TIP 40 (Treatment Improvement Protocols)

TIP 40The most downloaded item on TIP 40: Clinical Guidelines for the Use of Buprenorphine in the Treatment of Opioid Addiction. This best-practice guideline for the treatment of substance use disorders provides consensus- and evidence-based guidance on the use of buprenorphine for the treatment of opioid addiction.

All TIPs are available directly from the US Health Department in PDF and hardcopy form.

(TIP 39) Substance Abuse Treatment and Family Therapy
(TIP 41) Substance Abuse Treatment: Group Therapy
(TIP 42) Substance Abuse Treatment for Persons With Co-Occurring Disorders
(TIP 43) Medication-Assisted Treatment for Opioid Addiction in Treatment Programs
(TIP 44) Substance Abuse Treatment for Adults in the Criminal Justice System
(TIP 45) Detoxification and Substance Abuse Treatment

Order your own hard copies of TIPs for free from the US Health Department

NIDA "The Science of Addiction"

The Science of AddictionReleased February 13, 2007, this NIDA (National Institute on Drug Abuse) 30-page full-color booklet explains in layman's terms how science has revolutionized the understanding of drug addiction as a brain disease that affects behavior. NIDA hopes this new publication will help reduce stigma against addictive disorders.

NIDA Articles that address Research on Heroin

NIDA - Research on HeroinThis NIDA Notes Series "A Collection of articles that address Research on Heroin (NN0023) contains 17 studies and articles about heroin addiction, and the treatment of, including buprenorphine treatment.

WHO "Neuroscience of Psychoactive Substance Use and Dependence"

WHO 'Neuroscience of Psychoactive Substance Use and DependenceThis World Health Organization comprehensive scientific book on addiction includes basic neurobiology and specific information about various substances.

NIDA Science & Practice Perspectives

NIDA - Science & Perspectives"Practical Considerations for the Clinical Use of Buprenorphine" August, 2004. Written by practicing certified buprenorphine physicians, the guide provides a real world assessment of the methods and issues with using buprenorphine in an office based environment.

Subscribe NIDA Addiction Science & Clinical Practice (formerly known as Science & Practical Perspectives)

NIDA Research Monograph Series

NIDA - Research Monograph SeriesThis 1992 "Buprenorphine: An Alternative Treatment for Opioid Dependence" monograph is based on the papers and discussions from a technical review on "Buprenorphine: An Alternative Treatment for Opioid Dependence" held on March 16-17, 1989, in Rockville, MD. sponsored by (NIDA).


NeuropsychopharmacologyBuprenorphine Study: Effects of Buprenorphine Maintenance Dose on mu-Opioid Receptor Availability, Plasma Concentrations, and Antagonist Blockade in Heroin-Dependent Volunteers – Mark K Greenwald, Chris-Ellyn Johanson, David E Moody, James H Woods, Michael R Kilbourn, Robert A Koeppe, Charles R Schuster and Jon-Kar Zubieta (2003)

NIDA Science & Practice Perspectives

NIDA - Science & Practice Perspectives"The Neurobiology of Opioid Dependence: Implications for Treatment" 2002 "Opioid tolerance, physical dependence and addiction are all manifestations of brain changes resulting from chronic opioid use and misuse. The patient's struggle for recovery is in great part a struggle to overcome the effects of these changes..."

Treating Pain in Persons With Substance Use Disorders

NIDA - Treating Pain in Persons With Substance Use DisordersPain and addiction co-occur frequently, and each can make the other more difficult to treat. This article discusses the neurobiology and clinical presentation of pain and its synergies with substance use disorders, presents methodical approaches to the evaluation and treatment of pain that co-occurs with substance use disorders, and provides practical guidelines for the use of opioids to treat pain in individuals with histories of addiction.

U.S. Department of Justice

U.S. Department of JusticeThis publication from the Drug Enforcement Agency (DEA), "Drugs of Abuse" provides a non-medical look at addiction. Included are statistics, images of different substances and laws about drugs and drug trafficking. (2005)

SAMHSA Know Your Rights

SAMHSA - Know Your RightsPrivacy is a big concern. This publication covers special privacy rights afforded to patients with addiction.

SAMHSA Know Your Rights - MAT

SAMHSA - Know Your Rights - MAT Privacy is a big concern. This publication covers special privacy rights afforded to patients specifically utilizing MAT (Medication Assisted Treatment). It is illegal to deny housing based on MAT.


ScienceBibliography of major scientific publication with links to many study abstracts. A great place to start when looking for very specific research or information.

NIDA Principles of Drug Treatment

NIDA - Principals of Drug TreatmentA Research based guide National Institute on Drug Abuse. 1999

Alcoholic Anonymous

Alcoholic Anonymous Brochure"The AA Member – Medications & Other Drugs" AA's official publication regarding the use of medications - Revised 2011

Grand Jury for Baltimore City

Grand Jury for Baltimore City"Report of the Grand Jury for Baltimore City, January 2008 Term" Investigation of Buprenorphine treatment – 2008

The Facts about Buprenorphine for Treatment of Opioid Addiction

The Facts about Buprenorphine for Treatment of Opioid Addiction This short booklet provides basic information about the use of buprenorphine in medication-assisted treatment for opioid addiction. It describes how buprenorphine works, the proper use of the medication, and common side effects. It also explains how buprenorphine fits into the overall recovery process. The booklet is for patients entering medication-assisted treatment for opioid addiction, and it may be useful to patients' family members and friends. SAMHSA, 2009

TAP 30

TAP 30 This guide is intended to provide nurses with general information about buprenorphine products for the pharmacological treatment of opioid addiction.

The Purpose of Buprenorphine Treatment:

To suppress the debilitating symptoms of cravings and withdrawal, enabling the patient to engage in therapy, counseling and support, so they can implement positive long-term changes in their lives which develops into the new healthy patterns of behavior necessary to achieve sustained addiction remission. - explain -

The National Alliance of Advocates for Buprenorphine Treatment is a non-profit organization charged with the mission to:

  1. U.S. Food and Drug Administration, FDA Talk Paper, T0238, October 8, 2002, Subutex and Suboxone approved to treat opiate dependence.
  2. Center for Substance Abuse Treatment. Clinical Guidelines for the Use of Buprenorphine in the Treatment of Opioid Addiction. Treatment Improvement Protocol (TIP) Series 40. DHHS Publication No. (SMA) 04-3939. Rockville, Md: Substance Abuse and Mental Health Services Administration, 2004.
  3. Subutex Discontinued in the US market in late 2011.
  4. Zubsolv (bup/nx sublingual tablet) FDA approved 7/3/2013 see buprenorphine pipeline graphic -in pharmacies now.
  5. Bunavail (bup/nx bucal film) FDA approved 6/6/2014 see buprenorphine pipeline graphic -in pharmacies now.
  6. Probuphine FDA approved 5/26/2016 - FDA Probuphine press release